PnP-stable growth factors are biobetters that dramatically improve efficacy and formulation applicability by improving the intrinsically low thermal stability of native growth factors through the BexPress™ platform technology, the PnP Biopharm’s protein optimization platform technology (POP Tech™). PnP-stable growth factors are currently supplied as cosmeceutical raw materials, OEM and finished product in the fields of skin anti-aging, wrinkle removal and hair regeneration.
At the same time, a preclinical stage with a PnP-stable growth factor (PnP-001) is undergoing for the development of wound healing therapeutics treating burns and wounds.

The graph above shows the stability of the two PnP-stable growth factors (PnP-Stable EGF and PnP-Stable bFGF) compared with the stability of their native versions (wild-type EGF and wild-type bFGF) through a cell proliferation test. As shown in the graph, the activity of the PnP-stable growth factors is maintained over the time, while the activity of their native versions decreases significantly during the same period. This demonstrates that the higher stability of the PnP-stable growth factors plays a significant role in the maintenance of the cell proliferation activity.