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Core Technology

Pipeline

Product

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서브비주얼이미지 서브비주얼이미지
Core Technology
BexPress™
BexPress™ Platform

The BexPress™ platform technology is a specialized protein technology of PnP Biopharm that enables more economical mass production of protein through a high cell-density culture. Moreover, through this technology, a purpose-driven amino-acid mutation strategy can be efficiently applied, and thus it is highly possible to enhance the protein activity and stability as well as the production yield.

PnP-Stable Growth Factor

PnP-stable growth factors are biobetters that dramatically improve efficacy and formulation applicability by improving the intrinsically low thermal stability of native growth factors through the BexPress™ platform technology, the PnP Biopharm’s protein optimization platform technology (POP Tech™). PnP-stable growth factors are currently supplied as cosmeceutical raw materials, OEM and finished product in the fields of skin anti-aging, wrinkle removal and hair regeneration.
At the same time, a preclinical stage with a PnP-stable growth factor (PnP-001) is undergoing for the development of wound healing therapeutics treating burns and wounds.

Comparison of Stability

The graph above shows the stability of the two PnP-stable growth factors (PnP-Stable EGF and PnP-Stable bFGF) compared with the stability of their native versions (wild-type EGF and wild-type bFGF) through a cell proliferation test. As shown in the graph, the activity of the PnP-stable growth factors is maintained over the time, while the activity of their native versions decreases significantly during the same period. This demonstrates that the higher stability of the PnP-stable growth factors plays a significant role in the maintenance of the cell proliferation activity.

Applications of PnP-Stable Growth Factors

PnP-stable growth factors are currently supplied as cosmeceutical raw materials, OEM and finished product in the fields of skin anti-aging, wrinkle removal and hair regeneration. At the same time, a preclinical stage with a PnP-stable growth factor (PnP-001) is undergoing for the development of wound healing therapeutics treating burns and wounds. Growth factors are core factors of stem cell culture medium and are essential for the production of stem cell-derived therapeutics and organoids. Moreover, they are highly recognized as an indispensable materials for the production of exosomes and artificial meats, the fields highly promising. Therefore, PnP-stable growth factors with improved efficacy are receiving much attention and expectation as a cutting-edge biomaterials.